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Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn  and Facebook . Role Summary: The VP, U . S .  Medical Affairs is  the senior U.S.   medical leader with  end-to-end   accountability for U.S. medical launch readiness, execution, and early commercialization success for Dyne’s first approved product. This role  will continue to build ,  lead , and scale  a high-impact U.S .  Medical Affairs organization  and serve as a critical leader  capable of delivering excellence in a first-launch,  high ‑ visibility  environment.   This position plays a critical leadership role in shaping Dyne’s transition from a clinical-stage to a commercial-stage company, serving as a core member of cross-functional launch governance and a  trusted strategic advisor  to  e xecutive  l eadership  and member of the US Leadership Team (USLT) . The VP is accountable for defining and executing the U.S. medical strategy, ensuring scientific and medical excellence, mitigating medical risk, and driving impactful engagement with U.S. healthcare providers, payers, patient communities, and other external stakeholders.   The VP, U . S .  Medical Affairs is a key member of the Global Medical Affairs Leadership Team and works in close collaboration with Global Medical Affairs, Commercial, Market Access, Clinical Development, Regulatory, and other functions to ensure seamless alignment and execution through approval, launch, and early lifecycle management.   This is a unique opportunity to define and lead the U.S. medical strategy for Dyne’s first commercial product and  establish  the foundation for future launches in a rapidly evolving rare disease portfolio.   This role is based in Waltham, MA.   Primary Responsibilities  Include :   Deliver a highly effective U.S. medical launch that enables appropriate, evidence-based adoption    Establish a credible and trusted Dyne scientific presence with U.S. KOLs, payers, and patient communities    Build a scalable, high-performing Medical Affairs organization ready for multiple launches    Effectively translate scientific and clinical data into strategies that drive both access and lifecycle value   E stablish foundational capabilities and ways of working in a first-launch environment      Enterprise & Launch Leadership   Own U.S. medical strategy, launch readiness, and execution, with direct accountability for delivering  multiple successful product launches from a medical affairs perspective   Build and develop a strong leadership bench, establishing a leadership team capable of scaling with the organization and future launches   Serve as a core member of cross-functional launch leadership, shaping enterprise decisions  and influencing cross-functional tradeoffs, while  resolving complex scientific, medical, and operational balance in a time-critical environment   Ensure U.S. Medical Affairs capabilities, processes, g