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Natera is seeking a Staff Scientist to join our Early Research Team. The primary focus of this role is to independently lead the research and development of novel next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in molecular biology and NGS plus a proven track record of industrial R&D leadership. Primary Responsibilities: Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization. Define project goals and plans with input from stakeholders and manage multiple project streams in parallel. Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction. Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis. Mentor and guide junior scientists while promoting scientific rigor and best practices. Author high-quality protocols, technical reports, and study documentation. Communicate progress regularly to stakeholders, including departmental meetings and senior leadership. Contribute to risk management, strategy development, and continuous improvement of scientific workflows. Qualifications: Ph.D. in molecular biology, genomics, or a closely related field. Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry. Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology. Required Expertise: A strong technical foundation in molecular biology or chemistry. Deep mechanistic knowledge of NGS library preparation chemistry. Demonstrated ability to independently design and execute complex experiments (solid DOE skills). Creativity and ingenuity in solving high-ambiguity technical challenges. Experience leading research projects in an industrial setting. Preferred Skills: Experience with cfDNA or liquid biopsy assay development. Hands-on experience with NGS-based methylation detection and epigenomic workflows. Familiarity with translating early-stage research assays toward regulated product environments. Proficiency in statistical analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus. Compensation & Total Rewards  This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of  hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards Comprehensive health benefits (medical, dental, vision) 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range $157,300 — $196,600 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class inst