Job Opportunities API

Senior Scientist (Bioscience – Translational Biology) £41,700 - £51,300 plus   benefits Reports to:   Principal Scientist Directorate:   Research & Innovation Contract:   Permanent Hours:   Full time   35 hours per week Location:   Babraham Research Campus, Cambridge (Lab Based – Low flex with a minimum of 3 days per week on-site). Closing date:  Sunday 23rd August 23:55pm Recruitment process:   Initial screening call via MS Teams, followed by an in person competency-based interview  with presentation task. Interview dates: Screening calls: 2nd-4th September Second stage: 14th-16th September Visa sponsorship:   Cancer Research UK   can   consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application. At Cancer Research UK, we exist to beat cancer. We’re looking for a lab-based Senior Scientist to join Cancer Research Horizons (CRH) and play a key role in advancing our oncology and immuno‑oncology pipeline. You’ll design and deliver   critical translational studies   to inform project progression, develop and optimise   cell based assays using clinical relevant materials , and work closely with multidisciplinary teams to drive drug discovery decisions. This is an exciting opportunity for a proactive, detail‑driven scientist who thrives in a collaborative lab environment and is passionate about translating science into meaningful therapeutic progress. About Cancer Research Horizons As the world’s biggest medical research charity, we’ve helped bring fourteen new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. Cancer Research Horizons (CRH) is CRUK’s internal translation engine. CRUK’s established drug discovery teams operate under one organisation and leadership team. Our unique combination of cancer biology expertise and access to CRUK’s world-class academic network, coupled with cutting edge technology platforms and clinical expertise enables us to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based across sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, Cancer Research Horizons employs around 180 staff from both industry and academic backgrounds. Together, we are united by a shared commitment to accelerating the development of life-saving innovations and bringing forward the day when all cancers are cured Key Duties and Responsibilities • Lead   t ranslational assay development ,   linking preclinical findings to clinical relevance • Apply human tumour biopsy tissue, patient-derived material, and primary cells in drug discovery to integrate in vitro, ex vivo, and in vivo data and support project decision-making • Design ,   execute, and interpret   in vivo PK/PD and efficacy study (CDX, PDX)   for small molecules or   mAb , ADC programmes • D esign, perform complex cell culture, including 3D coculture experiments using patient derived materials • Conduct and interpret phenotypic analysis in cancer and immune cells including cell proliferation, apoptosis, colony formation • Review and critically appraise   published and unpublished   research to   identify   protocols for translational assay development • Demonstrate   strong problem-solving skills, ability to develop innovative solutions independently ,   and adapt effectively to rapidly changing drug discovery environment • Work collaboratively within the Bioscience team and interact with multi-disciplinary research teams both internally and with external collaborators • Communicate efficiently,  interpret  and summarise data and present them to different audiences • Prioritise work according to project goals and take responsibility for the  timely  delivery of his/her objectives • Maintain  accurate  and up to date electronic laboratory notebook • Maintain assigned laboratory equipment and/or duties • Perform all work  demonstrating  due care and attention to all health and safety regulations • Keep up to date with  state of the art  technologies and knowledge of developments in cancer therapeutics with particular focus   on    translational   model development • Highly committed, enthusiastic with a passion for learning Key Technical Skills,   Knowledge   and Experience • PhD   or equivalent   in a biological science . • Postdoctoral experience (or equivalent) in oncology and/or immunology research . • Expertise   in ex vivo translational models, particularly with patient derived materials, human tumour biopsies,   and/or MPS ( microphysiological   system) and NAM approaches (desirable but not essential) • Proven scientific leadership, with the ability to drive projects and influence research direction . • Industry research experience within pharma or biotech environments . • Strong knowledge of cell culture techniques, including   coculture, primary cell handling,   maintenance   and optimisation. • Hands ‑ on   experience with phenotypic assays, such as cell proliferation,   apoptosis   and   colony ‑ forming   assays Our organisation values are designed to guide all that we do. Bold:  Act with ambition,   courage   and determination Credible:  Act with rigour and professionalism Human : Act to have a positive impact on people Together:  Act inclusively and collaboratively We’re   looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer. If   you’re   interested in applying and excited about working with us but are unsure if you have the right skills and   experience   we’d   still love to hear from you. What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting   our   careers web page . How do I apply? We   operate   an anonymised shortlisting process in our commitment to equality,   diversity   and inclusion. CVs are   required   for all applications; but we   won’t   be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. For more information on this career opportunity please   visit our website   or contact us at   [email protected] . For more updates on our work and careers, follow us on:   Linked In ,   Facebook ,   Instagram ,   X   and   YouTube . Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented. We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact [email protected] or 0 20 3469 8400 as soon as possible. Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.