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Location :         London Reporting to: Executive Director, Translational Research   Job Summary Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts. This role is based in the heart of London in the Research facility of our Hammersmith headquarters.   The Senior Research Technician will be responsible for oversight and management of technical activities relating to core lentiviral vector production and cell & gene therapy analytical methods for the Department of Translational Research. The role requires a deep expertise in molecular biology with applications to C&GT, with experience of viral vector production and characterisation, and related analytical methods, in order to lead activities for the provision of core technical services for the Translational Research team. Candidates should also have project and staff management experience to direct core technical staff, including scheduling and allocation of core activities, as well as providing line management, guidance, training and mentorship. The role will also include provision of laboratory oversight to support the Translational Research teams activities on ensuring compliance with policies, procedures and best practices for an organised and effective working environment to support and optimise productivity and quality of research. The Senior Research Technician will work closely with Translational Research Leadership to work towards continuous improvements in our core technical activities, research quality, data integrity and laboratory practices.   Key Elements and Responsibilities: Senior Research Technician ·         Senior administrative and laboratory technical role responsible for enabling and optimising daily operations of Orchard’s core technical team to support the strategic goals of the Translational Research team. ·         Provide line management of Translational Research Core Technical team, including allocation of assignments, training and development of technical staff. ·         Oversee the coordination and processes of core Molecular Biology, Vector and Analytical activities provided for the Translational Research department, to align vector designs with production requirements, working with dedicated technical staff, and where required contribute directly to the delivery of: ·         Vector Design & Assembly: Generating and validating novel lentiviral vectors for ex vivo or in vivo therapeutic applications, using expertise in molecular biology, CRISPR, PCR, qPCR, ddPCR, molecular cloning, western blotting, and mammalian cell culture. ·         Production & Optimization: Producing lentivirus, optimising protocols and improving processes to provide high quality and consistent vector yields. ·         Analytical Testing: Performing assays to assess viral titer, potency, transduction efficiency and purity, and developing standardized protocols for vector performance. ·         Core LLV and Analytical Team Leadership: Providing expertise to support technical research staff, troubleshooting, updating protocols, and ensuring regulatory compliance. ·         Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity. ·         Lead dat