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“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone.  Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor.  Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit  https://mineralystx.com . Follow Mineralys on  LinkedIn ,  Twitter  and  Bluesky ” Mineralys is a fully remote company. The Senior National Account Director– Commercial Payers will report to the SVP, Market Access and play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first cardiovascular product launch. This is a high-impact, field-based position responsible for building relationships with key payer stakeholders, communicating product value, and securing favorable coverage and reimbursement pathways. This is a highly strategic, hands-on role that is ideal for an experienced national account professional who thrives in fast-paced, build-from-scratch environments and understands the complexity of securing access for innovative, high-value therapies. Responsibilities   Lead strategic engagement with national and large regional commercial PBMs and payers (e.g., UnitedHealthcare, ESI, Aetna, Anthem, Cigna, CVS/Aetna, Elevance, etc.). Build and manage relationships with key decision-makers across payer organizations. Analyze the competitive landscape and coverage policies to anticipate payer needs and barriers. Profile key payer accounts and execute account engagement plans to educate payer stakeholders on unmet need, science, disease burden, and anticipated value proposition. Identify and address potential barriers to access proactively to ensure product is well positioned for formulary and P&T reviews Identify competitive threats and develop strategies to ensure optimal coverage for lorundrostat. Lead pull-though initiatives that capitalize on formulary wins and lead push-though efforts in areas with access challenges Partner with internal teams (Market Access Strategy, Contracts and Pricing, HEOR, Medical Affairs, Clinical, Regulatory) to develop and tailor payer-facing materials, including early scientific exchange, evidence dossiers, PIE presentations, and budget impact models. If required, identify, shape, and lead negotiation of innovative contracting opportunities aligned with Mineralys Therapeutics, product profile, and payer priorities. Serve as the internal voice of the payer and provide strategic guidance to senior leadership on coverage risks, opportunities, and commercial landscape dynamics. Ensure all engagements and materials are fully compliant with legal, regulatory, and corporate standards.   Cross-Functional Integration & Collaboration Serve as a key commercial liaison across internal stakeholders, including Market Access Leadership, Medical Affairs, Marketing, Patient Services, Finance, and Regulatory, to ensure alignment on strategic initiatives and execution plans that support national account objectives. Collaborate with the Medical Value & Outcomes MSLs to support the communication and translation of complex scientific and economic value propositions into compelling narratives for diverse payer stakeholders. Collaborate with the Patient Support Services team to support the patient journey and resolve coverage issues. Assist Regional Sales teams with pull- or sell-through strategies based on payer coverage. Represent Mineralys at industry events, including Asembia, AMCP, and other relevant conferences. Lead cross-functional account planning sessions to synthesize market insights, anticipate cus