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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Senior Manager, People Operations, Europe will play a critical, hands-on role in building and scaling the HR operational infrastructure across Europe. This role will drive the execution of core HR operations in close partnership with internal and external stakeholders, with an immediate focus to support establishing payroll and benefits frameworks across multiple countries. This position requires a highly collaborative operator who can lead execution while navigating a global, matrixed environment, ensuring that regional needs are effectively represented while aligning with global standards. Key Responsibilities include: Support HR Operations Infrastructure Support execution of end-to-end HR operational processes across Europe (onboarding, offboarding, employee data management, lifecycle workflows) in partnership with global People/HR functions and Finance. Partner cross-functionally to ensure alignment of regional processes with global standards, while adapting to local requirements. Ensure operational readiness for new country expansions, coordinating closely with HR, Finance, Legal, and global teams. Payroll & Benefits Execution Support execution excellence of local infrastructure across multiple European countries in close partnership with Finance and global HR/People functions. Support the implementation of country-specific benefits programs in collaboration with Regional stakeholders, global Total Rewards, Finance, and external brokers. Ensure effective coordination between payroll, benefits, Finance, and global teams to enable accurate and compliant going operations. Serve as central point of contact for all European employees in HR operational matters. Compliance & Local Setup Ensure execution of compliant HR operational frameworks across countries, in partnership with HR, Legal, Finance, and global HR. Ensure documentation, contracts, and employee records processes meet both local and global standards. Systems & Technology (HRIS & TA Systems) Support regional execution and readiness for system deployments, ensuring alignment with global implementation timelines and milestones. Collaborate closely with global system owners to ensure European country-specific requirements (e.g., local regulations, data fields, workflows) are understood, prioritized, and incorporated into system design where appropriate. Support user acceptance testing (UAT), data validation, and go-live readiness activities for European markets in partnership with global teams. Ensure effective adoption of systems across the region through clear processes, documentation, and stakeholder alignment. Partner cross-functionally (HR, TA, Finance, IT) to ensure systems support compliant and efficient end-to-end processes. Cross-Functional Collaboration & Execution Support execution excellence of regional and local HR operations. Partner closely with relevant internal and external stakeholders regionally, locally and globally  in European expansion efforts. Proactively identify and resolve gaps or dependencies across