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JOB SUMMARY We are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and execution for one or more assets from IND-enabling activities through first-in-human and early efficacy studies. You will serve as the clinical and scientific lead on cross-functional program teams, working closely with our discovery, translational, regulatory, and clinical operations groups — and directly alongside our AI/ML platform teams — to translate novel candidates into well-designed clinical programs. This position will be based in our San Diego Headquarters. Title and scope will be calibrated to the successful candidate's experience. KEY RESPONSIBILITIES - Serve as the clinical/medical lead for early-stage oncology programs, owning the clinical development strategy from IND through Phase 1 and early proof-of-concept. - Author and drive the clinical components of IND submissions, including protocols, investigator's brochures, and clinical sections of regulatory documents; support and participate in health authority interactions (e.g., pre-IND, EOP1). - Design first-in-human and early-phase oncology trials, including dose-escalation and dose-optimization strategies, biomarker and translational plans, and eligibility criteria. - Provide ongoing medical monitoring and safety oversight for active trials, including review of emerging safety data, dose decisions, and management of study conduct in partnership with Clinical Operations and Pharmacovigilance. - Partner with translational science and the AI/ML platform teams to define patient selection strategies, pharmacodynamic endpoints, and data-driven development hypotheses. - Engage key opinion leaders, investigators, and study sites; represent programs to internal governance, partners, and, as appropriate, external stakeholders. - Collaborate cross-functionally with Regulatory Affairs, CMC, Clinical Operations, Biostatistics, and Program Management to keep programs on strategy and on timeline. - Contribute to portfolio-level decisions, candidate selection input, and business development / due diligence as needed. QUALIFICATIONS - M.D. or D.O. (or international equivalent); board eligibility/certification in hematology/oncology or medical oncology strongly preferred; exceptional candidates with PharmD and relevant oncology and clinical experience will be considered - Meaningful drug-development experience in biotech or pharma. We anticipate roughly 5+ years for a Senior Medical Director and 8–10+ years for an Executive Medical Director; strong candidates across this range are encouraged to apply. - Direct, hands-on experience authoring and executing IND submissions. - Direct experience designing and running Phase 1 / early-phase oncology clinical trials. - Demonstrated experience with oncology assets and a strong understanding of the oncology therapeutic and drug-development landscape. - Working knowledge of GCP, ICH guidelines, and the global regulatory environment for oncology development. PREFERRED QUALIFICATIONS - Experience with small-molecule oncology programs and targeted therapies. - Experience taking a program from candidate nomination or IND through clinical proof-of-concept. - Comfort working in a fast-paced, data-rich, technology-forward environment and collaborating with computational and platform teams. - Prior experience presenting to health authorities and/or supporting BD due diligence ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical tr