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Scientist II - Manager, PD Upstream

Forge Biologics
CompanyForge Biologics
CategoryScience & Research
LocationColumbus
RemoteOn-site (inferred)
EmploymentNot stated
LevelManager
SalaryNot stated by the employer
Posted10 Apr 2026
Last verified11 Aug 2026
SourceEmployer ATS (greenhouse)
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Description
Forge Your Future with Us: At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities — all united by one goal: improving lives. If you’re driven by purpose and excited to make a tangible impact, this is where your journey begins. Our team works out of The Hearth, a state-of-the-art, 200,000-square-foot cGMP facility in Columbus, Ohio. Here, you won’t just watch innovation happen — you’ll be part of it. Whether you’re scaling AAV manufacturing, collaborating on cutting-edge therapies, or supporting complex technical projects, you’ll play a key role in bringing hope to patients with genetic diseases. What sets Forge apart is our culture of  H.O.P.E.  We are  hardworking , showing up each day with determination and grit. We are  open , creating a space where ideas flow freely, and every voice is valued. We are  purpose-driven , with every task directly tied to changing lives. And we are  engaged , energized by the challenges we face and the milestones we achieve together. At Forge, your growth matters. We’re committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands-on learning, and opportunities for advancement. Our people are our greatest investment, and we’re proud to see team members grow with us. If you’re ready to use your talent to help deliver hope to patients around the world, join us — and be part of something bigger than yourself.   About The Role:    The Scientist II provides active leadership and execution of the laboratory experiments and protocols for upstream process development efforts. This individual will lead projects and complex experiments, train junior scientists, and actively contribute to the advancement of AAV manufacturing processes.     Responsibilities:   Senior-level technical contributor and subject matter expert for upstream systems and process strategy   Independently manages multiple projects or client programs simultaneously,  maintaining  a high degree of quality, scientific rigor, and compliance   Leads process development activities for early- to late-stage programs, including scale-up, technology transfer, and validation support   Designs and executes complex DoE studies, authors technical reports, and contributes to regulatory documentation   Anticipates challenges in upstream scale-up and proactively develops solutions to ensure technical success   Acts as a key liaison between Process Development, Manufacturing, and Quality teams to align on strategy and ensure smooth GMP execution   Contributes scientific rationale for tech transfer packages and GMP documentation without owning official SOPs or batch records   Mentors  junior scientists and associates through day-to-day technical guidance, fostering development in experimental design, documentation standards, and scientific reasoning     Qualifications:   Bachelor’s Degree in Chemical Engineering , Bio e ngineering, Biology, or related discipline (or equivalent experience)   Working knowledge of cell culture techniques  utilizing  mammalian   cells   Proven ability to  operate  and troubleshoot bioreactors   Experience planning,  conducting  and reviewing experimental data with minimal oversight   E xperience training and development of other team members   Experience analyzing data s