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What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. OUR OPERATING PRINCIPLES - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! YOU’RE THE RIGHT FIT FOR SHASQI IF YOU.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. POSITION OVERVIEW We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting. You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment. KEY RESPONSIBILITIES STRATEGY & LEADERSHIP - Define and execute ADME/PK strategies for pre-targeted therapeutics that consist of biologics and small molecules. - Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs. - Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure. - Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics. PRECLINICAL DEVELOPMENT - Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development. - Collaborate with bioanalytical assay development team to support assay development. MODELING & TRANSLATION - Build and apply PK/PD and mechanistic models to predict human dosing and scheduling. - Translate preclinical data into clinical hypotheses and first-in-human strategies. COLLABORATION & COMMUNICATION - Work closely with CMC and analytical teams to ensure bioanalytical readiness. - Partner with toxicology and regulatory teams to support IND-enabling studies. - Present data and strategy to leadership, investors, and external collaborators. REQUIRED QUALIFICATIONS - PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field. - 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs. - Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics). - Strong experience designing and interpreting in vivo PK and biodistribution studies. - Demonstrated experience with QSP and PK/PD modeling. - Experience wit