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At the Ellison Institute of Technology (EIT), we’re on a mission to translate scientific discovery into real world impact. We bring together visionary scientists, technologists, engineers, researchers, educators and innovators to tackle humanity’s greatest challenges in four transformative areas: Health, Medical Science & Generative Biology Food Security & Sustainable Agriculture Climate Change & Managing CO₂ Artificial Intelligence & Robotics This is ambitious work - work that demands curiosity, courage, and a relentless drive to make a difference. At EIT, you’ll join a community built on excellence, innovation, tenacity, trust, and collaboration, where bold ideas become real-world breakthroughs. Together, we push boundaries, embrace complexity, and create solutions to scale ideas from lab to society. Explore more at www.eit.org . Welcome to the Institute of Materials & Devices for Life Sciences (MDLS): The vision for the Institute of Materials & Devices for Life Sciences (MDLS) at the Ellison Institute of Technology is to advance human health by scaling interdisciplinary science at the interface of chemistry, biology and engineering. Led by Professor Hagan Bayley, it will house more than 100 researchers engaging in three interrelated endeavors; Nanopore Sensing and Sequencing, 3D Tissue Construction, and Device Engineering. The MDLS Institute will expand nanopore science to detect a wider range of biological molecules, including volatiles in human breath. While in parallel, pioneering novel methods that integrate synthetic and living tissues into structures for organ repair. All the research will be underpinned by the development of new devices capable of serving as powerful tools in clinical settings. Your Role: At EIT we are seeking an experienced and detail orientated Postdoctoral Protein Scientist to join a multidisciplinary research group developing nanopore technology for single-molecule sensing, based at the MDLS EIT (first 6 months based at the Department of Chemistry, University of Oxford). The role will design, engineer, and prepare protein tools, including protein nanopores and enzymes, to support the group's technology development programme. The postholder will bring strong protein engineering, protein preparation, and molecular biology skills, and be technically excellent and reliable, with the ability to deliver proteins on demand and work with a genuine sense of urgency. They will engage directly with colleagues from physical and engineering science backgrounds, translating protein and biological requirements into device-ready tools, and should be comfortable working at this interface. The ideal candidate is a self-starter who works well independently, is open to learning and adopting new protein techniques, and is proactive in bringing new methods into the team. Key Responsibilities: Carry out molecular cloning and construct design, including plasmid design, Gibson/Golden Gate assembly, and site-directed mutagenesis. Express proteins using bacterial-, mammalian-cell-based (e.g., E. coli, HEK293), and cell-free protein expression systems, selecting the appropriate route for each project. Purify proteins by FPLC, including affinity (IMAC), ion exchange, and size-exclusion chromatography. Characterise and quality-control protein preparations (e.g. SDS-PAGE, Western blotting, mass spectrometry, DLS, thermal stability assays, CD spectroscopy) and set acceptance criteria before proteins are used in functional assays. Apply protein engineering approaches (rational, structure-guided, and/or directed evolution) to optimise nanopore and related protein tools for specific sensing applications. Manage, update, and maintain the group's inventory and library of in-house plasmids and protein preparations, ensuring records are accurate, well organised, and easily retrievable. Establish and document clear protocols and SOPs for protein engineering and preparatio