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Unsere Arbeit bei Lilly ist anspruchsvoll, weil Patienten unsere Medikamente benötigen. Mit unserer Forschungsarbeit verfolgen wir das Ziel, das Leben von Menschen auf der ganzen Welt besser zu machen. Dabei ist uns bewusst, dass jede Entscheidung, jedes Detail und jeder Tag zählt. Unser Hauptsitz befindet sich in Indianapolis im US-Bundesstaat Indiana. Mit über 50.000 Mitarbeitern auf der ganzen Welt stellen wir uns komplexen Herausforderungen, um bahnbrechende Medikamente zu entwickeln und auf den Markt zu bringen, unsere Kenntnisse über Gesundheit und die Behandlung von Krankheiten zu verbessern und Patienten zu unterstützen. Dies ist eine intensive, vordringliche und aufopferungsvolle, aber dennoch erfüllende Tätigkeit. Wenn du motiviert und bereit bist, dein Bestes für eine Aufgabe zu geben, die für Patienten wirklich zählt, würden wir uns freuen, dich in unserem Team willkommen zu heißen. Overview : At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. Position   Summary : The Upstream Process Development group within our BR&D organization is seeking a Postdoctoral Fellow to join a team of scientists and engineers focused on developing and optimizing   mammalian cell culture   processes for recombinant proteins and other modalities for early- and late-phase clinical trials. This role will focus on developing and applying innovative mathematical and computational modeling approaches to characterize, understand, and predict the complex biological systems used in mammalian cell culture. The fellow will build mechanistic and data-driven models, including genome-scale and hybrid metabolic models, to predict cellular behavior, diagnose process bottlenecks, and rationally guide the design of feeding strategies and medium compositions. Where current development often relies on iterative   empirical screening, this position aims to establish a model-guided approach that narrows the experimental search space before committing significant laboratory effort. The fellow will also explore the use of these models within real-time monitoring and control frameworks, and will leverage machine learning to enable earlier, model-informed decisions such as clone selection based on predicted process performance. The work establishes a closed-loop cycle in which model predictions are validated experimentally and the resulting data continuously improves model accuracy. This position is well suited to a highly motivated scientist who wants to bridge computational modeling an d hands-on bioprocess experimentation. Responsibilities : • Develop and calibrate mechanistic and hybrid metabolic models of mammalian cell culture processes, integrating process data to predict cellular behavior and identify performance-limiting factors. • Build computational pipelines that turn routine bioprocess data into model inputs and generate predicted metabolic flux distributions across the culture cycle. • Apply machine learning and data-driven methods   for performance prediction and to integrate model-derived features with experimental data. • Use calibrated models to evaluate feeding strategies and medium compositions   to   enhance productivity. • Design and execute cell culture experiments—from shake flask to bench-scale bioreactors—to generate datasets for model development, training, and validation. • Collaborate with   the   Analytical team to develop multi-omics   method s for metabolic model calibration. • Integrate model-derived features into machine learning workflows to support earlier decisions, including predictive clone selection from earlier-stage process data. • Investigate AI-assisted approaches to accelerate model building, validation, and reuse across projects, with human-in-the-loop decision support. • Maintain rigorous documentation, communicate results through technical reports, presentations, and peer-reviewed publications, and collaborate across cross-functional teams. Basic   Requirements : • PhD in Chemical/Biochemical Engineering, Bioengineering, Systems Biology, Computational Biology, Metabolic Engineering, or a related field. • Experience with constraint-based or genome-scale metabolic modeling. • Hands-on experience designing and executing cell culture experiments   with a working   understanding of   B atch,   F ed- b atch ,   and   I ntensified   P rocess es . • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. Additional Preferences : • Strong foundation in mathematical modeling, reaction kinetics, and mammalian cell culture. • Proficiency in Python, MATLAB ,   or similar scientific programming languages . • Familiarity with process control concepts, including model predictive control or dynamic optimization. • Understanding of mammalian (e.g., CHO) cell physiology and metabolism relevant to bioprocessing. • Experience with analytical methods such as HPLC, UPLC, and mass spectrometry is a plus. • Experience integrating omics data with mechanistic or hybrid models. • Demonstrated expertise in machine learning and data-driven modeling is a plus. Additional Information : • This position is part of Lilly’s postdoctoral training program, which provides an exceptional environment and the opportunity for professional growth through learning, collaboration, networking, and mentorship from Lilly’s leading scientists, aimed at facilitating groundbreaking discoveries. • This position is not permanent. It is for a fixed duration of two years with the potential to extend to a maximum of 4 years. You will have opportunities to apply for full-time positions after your duration is complete. About Eli Lilly’s Postdoctoral Scientist Program: When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive, and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology, and chemistry — ultimately bringing new solutions one step closer to reality.   Over the course of our history, we have shed light on some of the toughest health care problems known to   humankind— diabetes, heart disease, infectious diseases, neuroscience disorders, cancer, and more. We could not pursue this without our research and development team. Postdoctoral scientists help us continue this pursuit. During your experience you will get: • Top industry research experience • Mentoring by some of Lilly’s top scientists • Laboratory and classroom training and education to further your development • Collaboration and networking across dozens of postdoctoral scientists and other researchers Physical Demands: • The physical demands of this job are consistent with a lab environment. • The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Work Environment: • This position’s work environment is in a laboratory. • The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. • *To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable   accommodations   may be made to enable individuals with disabilities to perform the essential functions. Lilly setzt sich dafür ein, dass Menschen mit Behinderungen aktiv am Arbeitsleben teilnehmen und bei der Bewerbung um eine Stelle die gleichen Chancen haben. Wenn für dich Anpassungen vorgenommen werden müssen, damit du einen Lebenslauf für eine Stelle bei Lilly einreichen kannst, fülle bitte das Antragsformular für Anpassungen ( https://careers.lilly.com/us/en/workplace-accommodation ) aus, um weitere Unterstützung zu erhalten. Bitte beachte, dass dieses Angebot sich nur an Personen richtet, die im Rahmen des Bewerbungsverfahrens Anpassungen beantragen. Sonstige Anfragen werden nicht beantwortet. Lilly ist stolz darauf, ein Arbeitgeber zu sein, der sich die berufliche Chancengleichheit auf die Fahne geschrieben hat. Bei uns erfolgt keine Benachteiligung aufgrund von Alter, Ethnie, Hautfarbe, Religion, körperlichem Geschlecht, geschlechtlichem Ausdruck, sexueller Orientierung, genetischen Informationen, Abstammung, nationaler Herkunft, Veteranenstatus, Behinderung oder einem sonstigen gesetzlich geschützten Status. Unsere Mitarbeiterressourcengruppen (ERGs) bieten Mitgliedern solide Unterstützungsnetzwerke und stehen allen Mitarbeitern offen. Zurzeit gibt es unter anderem folgende Gruppen: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) und Women’s Initiative for Leading at Lilly (WILL). Die tatsächliche Vergütung hängt von der Ausbildung, der Erfahrung, den Fähigkeiten und dem geografischen Standort eines Bewerbers ab.  Das voraussichtliche Gehalt für diese Position beträgt $58,000 - $123,200 Mitarbeiter in Vollzeitäquivalenten haben ebenfalls Anspruch auf einen Unternehmensbonus (teilweise abhängig von der betrieblichen und individuellen Leistung). Darüber hinaus bietet Lilly berechtigten Mitarbeitern ein umfassendes Leistungsprogramm an, einschließlich der Berechtigung zur Teilnahme an einem vom Unternehmen gesponserten 401(k); Pension; Urlaubsleistungen; Anspruch auf medizinische, zahnärztliche, augenärztliche und verschreibungspflichtige Leistungen; flexible Leistungen (z. B. flexible Ausgabenkonten für Gesundheitsversorgung und/oder abhängige Kindertagespflege); Lebensversicherungen und Todesfallleistungen; bestimmte Leistungen bei Freizeit und Beurlaubung; und Leistungen für das Wohlbefinden (z. B. Mitarbeiterunterstützungsprogramm, Fitnessvorteile sowie Mitarbeiterclubs und -aktivitäten). Lilly behält sich das Recht vor, seine Vergütungs- und Leistungsprogramme nach eigenem Ermessen zu ergänzen, zu modifizieren oder zu beenden, und die Vergütungspraktiken und -richtlinien von Lilly gelten in Bezug auf die Einzelheiten einer Beförderung oder Versetzung von Lilly-Mitarbeitern. WeAreLilly