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Postdoctoral Associate - Cancer biology and bioinformatics Job Details | Baylor College of Medicine Explore Careers Connect With Us Search Jobs Explore Careers Connect With Us Search Jobs Job Description Job Title: Postdoctoral Associate - Cancer biology and bioinformatics Division: Molecular and Cell Biology Work Arrangement: Onsite only Location: Houston, TX Salary Range: $62,232 FLSA Status: Exempt Work Schedule: Monday – Friday, 8 a.m. – 5 p.m. Summary Dr. Putluri’s laboratory at Baylor College of Medicine is seeking a highly motivated and talented Postdoctoral Fellow to join our multidisciplinary cancer research team. The lab is seeking a highly motivated Postdoctoral Associate with strong expertise in cancer biology or molecular biology, and additional skills in bioinformatics/data analysis, to join our multidisciplinary research team at Baylor College of Medicine. The Postdoctoral Associate will work on cutting-edge translational cancer research projects involving tumor cell signaling, metabolic reprogramming, immuno-oncology, and therapeutic target identification. The lab focuses on understanding metabolic and molecular vulnerabilities driving cancer progression, therapeutic resistance, and tumor–immune interactions. This position offers opportunities to work with cutting-edge cancer models, 3D culture systems, and translational human samples. This position offers the opportunity to work with state-of-the-art platforms, including patient-derived models (PDXs), 3D organoids/spheroids, advanced molecular assays, and multi-omics datasets. Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates. Job Duties • Conducts in vitro cancer biology experiments, including 2D culture, 3D organoids, spheroids, and patient-derived models. • Performs CRISPR/Cas9-mediated gene knockout (KO), siRNA/shRNA-mediated knockdown (KD), and validation of engineered cell lines. • Conducts the multi-omics data analysis including RNA-seq, proteomics, metabolomics, ChIP-seq, single-cell RNA-seq, and spatial data and multi-omics data integration. • Executes molecular and biochemical assays such as qPCR, Western blotting, ELISA, flow cytometry, and functional phenotyping. • Contributes to the generation and characterization of knockout (KO) mouse models, including colony maintenance, genotyping, and phenotypic analysis. • Performs mouse studies using immune-competent strains and immune-compromised NSG mice that includes tumor implantation, drug treatment, and immune profiling. • Establishes and monitors orthotopic xenograft models to study tumor growth and progression within relevant tissue microenvironments. • Conducts luciferase labeling of cancer cells and use bioluminescence imaging to trace tumor growth and metastasis in vivo. • Performs mechanistic studies examining cancer signaling pathways, cytokine biology, therapeutic resistance, and tumor metabolism. • Designs and executes xenograft, orthotopic, syngeneic, and PDX in vivo studies. • Develops and maintains 3D organoids/spheroids and support in vivo therapeutic testing. • Collaborates with experimental biologists, computational biologists, and clinicians to drive mechanistic and translational outputs. • Prepares manuscripts, figures, and grant-related materials, and organize data for grant/paper submissions. • Presents research findings at internal meetings and national/international conferences. • Mentor’s students and support collaborative projects across laboratories. • Performs other job-related duties as assigned. Minimum Qualifications • MD or Ph.D. in Basic Science, Health Science, or a related field. • No experience required. Preferred Qualifications • Strong coding experience using R and Python for data analysis. • Expertise in the biological interpretation of multi-omics datasets (RNA-seq, proteomics, metabolomics, ChIP-seq, single-cell RNA-seq, and spatial data) and experience in multi-omics data integration. • Has the ability to develop algorithms and code for innovative multi-omics data analysis. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer. Nature; PD; SN Requisition ID: 25492 Opens in a new tab. Opens in a new tab. Opens in a new tab. Opens in a new tab. Opens in a new tab. Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.