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The University of Gothenburg tackles society's challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. https://web103.reachmee.com/ext/I005/1035/job?site=7&lang=UK&validator=9b89bead79bb7258ad55c8d75228e5b7&job_id=39310 Subject area Single-cell genomics and functional imaging of kidney epithelial injury Subject area description The project aims to develop and apply novel experimental methods to study functional heterogeneity in proximal tubular epithelial cells (PTECs) during kidney injury. By combining direct measurements of albumin reabsorption with single-cell transcriptomics, the project seeks to identify molecular programs underlying epithelial dysfunction and to discover targetable pathways relevant to kidney disease. Duties The successful candidate will lead experimental work across multiple PTEC injury models, including toxic, metabolic, inflammatory, and hypoxia–reoxygenation stress. Key tasks include functional uptake assays using fluorescently labelled albumin, cell and tissue imaging, preparation of single-cell RNA sequencing libraries, data generation from primary human PTECs and acute kidney slices, and close collaboration with computational researchers for downstream analysis. Validation of candidate pathways in tissue slices will be an additional component of the work. Eligibility The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area. Assessment criteria The ideal candidates should have: PhD in Molecular or Cell Biology, or a related life science discipline Experience in cell-based assays and tissue culture Experience with molecular biology techniques (RNA extraction, qPCR, NGS library preparation) Experience with microscopy techniques, and analysis tools (e.g. Fiji) Knowledge of single-cell RNA sequencing methods Experience with functional assays in epithelial cells or kidney-related models Experience with FACS Experience analyzing high-dimensional biological data (Python) Ability to work independently, plan experiments, and troubleshoot High level of motivation, accuracy, and organizational skills Fluency in English Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance Employment The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed. Selection process https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply-for-a-position Contact information If you have any questions about the position, please contact Dr. Joan Camuñas Soler: [email protected] Unions Union representatives at the University of Gothenburg can be fou