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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: Revolution Medicines is seeking a motivated and experienced Manager, Commercial Supply Chain to lead and optimize global distribution and logistics operations supporting commercial pharmaceutical products. This role is responsible for ensuring the compliant, timely, and efficient movement of GMP materials and finished goods across manufacturing sites, depots, CMOs, and 3PL partners. The successful candidate will partner cross-functionally to support commercial scale-up, global distribution expansion, and supply continuity initiatives while driving operational excellence, compliance, and continuous improvement across the commercial supply chain network. Responsibilities: Plan and execute global distribution and end-to-end logistics operations for commercial products across manufacturing sites, CMOs, depots, and 3PL partners, ensuring compliant shipment execution, documentation, carrier coordination, and on-time delivery performance. Oversee GMP and temperature-controlled product movements while managing excursions, deviations, investigations, and CAPAs in partnership with Quality. Manage global trade compliance programs, including import/export controls, customs requirements, broker management, and regulatory compliance. Develop and execute shipping validation strategies, including drafting protocols, reports, and related GMP documentation for qualified transportation lanes and packaging systems. Maintain ERP system accuracy to support inventory integrity, batch traceability, shipment documentation, and operational reporting. Monitor logistics KPIs, freight spend, and operational performance metrics to drive continuous improvement, cost optimization, and supply continuity. Support operational budgeting activities, including freight spend tracking, invoice review, accrual support, and cost optimization. Partner cross-functionally with Manufacturing, Quality, Regulatory, Clinical Supply, and external logistics providers to support uninterrupted product supply, audit readiness, SOP management, and business continuity initiatives. Required Skills, Experience and Education: B.Sc. or M.Sc. in a scientific field with 5+ years of experience in pharmaceutical supply chain. Experience managing cold chain logistics and temperature-sensitive pharmaceutical products in a GMP/GDP-regulated environment. Experience with shipping validation activities, including authoring protocols, reports, and related GMP documentation. Working knowledge of global import/export regulations, customs procedures, and trade compliance requirements. Strong understanding of pharmaceutical commercial manufacturing, quality systems, and end-to-end supply chain processes. Proficiency with ERP systems, inventory management, and shipment documentation practices. Demonstrated project management, problem-solving, and cross-functional collaboration skills. Excellent verbal and written communication skills with the ability to effectively manage multiple priorities in a fast-paced environment. Self-motivated, detail-oriented team player with the ability to navigate ambiguity and drive c