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About SonoThera:   SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.   The Role: The Facilities Manager/ Senior Facilities Manager will oversee the infrastructure, maintenance, and continuous improvement of SonoThera’s laboratory and manufacturing environment. This role is essential to ensuring uninterrupted, compliant operations of key utilities — including HVAC, RODI water systems, and compressed dry air (CDA) — and the complex laboratory equipment that supports our scientific and production goals. As SonoThera transitions to a new facility, this individual will lead the buildout coordination, establish operational processes, and serve as the primary owner of facility readiness. The Facilities Manager/ Senior Facilities Manager will partner closely with Laboratory Operations, EH&S, IT, and scientific departments to build a safe, efficient, and fully compliant environment that scales with company growth. What You Will Do: Facility Operations & Maintenance: Oversee preventive maintenance and repair of building systems and critical laboratory infrastructure, including HVAC, RODI water, compressed dry air (CDA), electrical, and plumbing. Manage the maintenance and service schedules for complex laboratory hardware such as autoclaves, bioreactors, incubators, biosafety cabinets, and cold-chain storage systems. Establish asset tracking and calibration records for all facility-managed equipment to support ongoing compliance and service continuity. Coordinate with building management and landlord representatives on lease-related facility matters, repairs, and capital improvement work. Compliance & Safety: Enforce applicable regulatory standards governing laboratory and manufacturing facility operations, and maintain associated documentation. Partner with the EH&S Specialist to ensure facility operations comply with OSHA, fire code, building codes, and hazardous material handling regulations. Coordinate fire suppression, emergency egress, and safety system inspections; maintain all compliance records. Support biosafety programs, chemical hygiene plans, and hazardous waste management in collaboration with EH&S and lab operations. Vendor & Contract Management: Source, negotiate, and manage service contracts for facility-related vendors including janitorial, pest control, waste management, security, and specialty lab equipment service providers. Monitor vendor performance against SLAs, manage escalations, and maintain a preferred vendor list. Work with Finance and Operations to track facility spend against budget and flag variances or unplanned costs. Space Planning & Capital Projects: Lead the facility move-in process, coordinating vendor installations, equipment commissioning, and space readiness for scientific and operational teams. Manage facility reconfigurations and expansions in collaboration with engineering, operations, and scientific teams. Maintain accurate floor plans, space assignments, and room inventory for all departments; anticipate growth-driven space needs. Partner with construction and fit-out contractors to deliver tenant improvements on schedule and within budget. SOP Development & Compliance Audits: Draft, review, and maintain Standard Operating Procedures (SOPs) for facility use, equipment access, and infrastructure management. Conduct routine facility compliance audits and walkthroughs; document findings and drive correctiv