Job Opportunities API

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.   4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics with potential to transform treatment paradigms and provide unprecedented benefits to patients. The Company’s lead product candidate 4D-150 is designed to be a backbone therapy forming the foundation of treatment of blinding retinal vascular diseases by providing multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single, safe, intravitreal injection, which substantially reduces the treatment burden associated with current bolus injections. The Company’s lead indication for 4D-150 is wet age-related macular degeneration, which is currently in Phase 3 development, and second indication is diabetic macular edema. The Company’s second product candidate is 4D-710, which is the first known genetic medicine to demonstrate successful delivery and expression of the CFTR transgene in the lungs of people with cystic fibrosis after aerosol delivery GENERAL SUMMARY The Executive Medical Director will report to the CMO, with a dotted-line relationship to the SVP of Research & Early-Stage Product Development, and will be responsible for the design, execution, and analysis of clinical trials in the ophthalmology therapeutic area MAJOR DUTIES & RESPONSIBILITIES:   Clinical Development Leadership Serve as the clinical lead for Phase 1 retina clinical trials, including study design, protocol development, dose escalation strategy, and safety oversight Maintain accountability for study execution, data interpretation, and clinical readouts, including early signal detection and go/no-go recommendations Serve as medical monitor for assigned studies, ensuring subject safety and data integrity Lead cross-functional study teams (clinical operations, clinical science, biometrics, regulatory, safety, CMC, etc.) to ensure high-quality and timely trial delivery Provides clinical leadership to multidisciplinary study execution teams drawn from clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharm/tox, drug safety, commercial, and alliance partners Has lead accountability on the study teams for delivery of study protocols, study conduct, and study readouts Biomarker & Translational Strategy Lead development and implementation of biomarker strategies for GA and broader retina programs Collaborate with research and translational teams to identify, validate, and integrate imaging, molecular, and functional biomarkers into early-phase trials Ensure biomarkers are aligned with mechanism of action, dose selection, and clinical endpoints to support decision-making and regulatory strategy Regulatory & Clinical Documentation Serve as the primary clinical author of development plans, protocols, IBs, INDs, CSRs, and regulatory responses Lead clinical contributions to IND submissions and early regulatory interactions, including Health Authority meetings for Phase 1 programs Ensure accuracy, scientific rigor, and regulatory compliance of all clinical documents External Scientific Leadership Organizes and leads scientific advisory board meetings. Interacts with external experts and stakeholders to gather input.  Works with the research organization and the portfolio management team to identify and support new project opportunities. Collaborates to identify program risks, and to create and implement mitigation strategies Other duties as assigned   QUALIFICATIONS:   Education:  Medical Degree (M.D.),