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Position Summary The Director, Human Resources Business Partner (HRBP) serves as a strategic advisor and trusted partner to leaders across Research, Clinical Development, and General & Administrative (G&A) functions, partnering to build organizational capability, strengthen leadership effectiveness, and enable Relay Therapeutics’ continued growth. Reporting to the Senior Director, People Partner, this role provides strategic HR leadership across assigned client groups while partnering closely with HR leadership to evolve Relay’s people strategy and operating model. The Director will independently lead complex organizational initiatives, coach leaders through growth and change, and drive scalable talent and organizational effectiveness solutions that support business priorities. This role is ideal for an experienced HRBP who thrives in a dynamic, science-driven environment and can seamlessly navigate between senior-level partnership, strategic problem-solving, and hands-on execution. Key Responsibilities Strategic HR Business Partnership Serve as the primary HRBP for Research and G&A functions, while partnering with the Senior Director, HRBP to support strategic initiatives and provide HR partnership across the Clinical Development organization. Translate business strategy into people strategies that strengthen organizational effectiveness, talent capabilities, and team performance. Coach leaders at all levels on leadership effectiveness, organizational health, performance management, employee relations, and change leadership. Partner with leaders on organizational design, workforce planning, talent strategy, succession planning, and team effectiveness. Provide thoughtful, data-driven insights and recommendations to help leaders make informed people decisions. Identify organizational opportunities and proactively develop solutions that improve employee experience and business outcomes. Organizational Effectiveness & Talent Strategy Lead and influence organizational effectiveness initiatives that enable Relay’s continued growth and evolution. Partner with leaders to assess organizational needs, optimize team structures, and strengthen capabilities required for future business priorities. Drive talent management processes, including talent reviews, succession planning, and development planning. Partner with leaders and Talent Acquisition to develop workforce strategies, anticipate talent needs, and support critical hiring priorities. Leverage employee engagement data, people analytics, and organizational insights to identify trends and recommend actions. Enterprise People Programs & HR Strategy Partner with HR leadership to design, implement, and continuously improve scalable people programs aligned with Relay’s culture and business needs. Own execution and evolution of key talent initiatives, including: Performance Management, Talent Reviews & Succession Planning, Employee Engagement & Pulse Surveys and Leadership Development Identify opportunities to improve HR processes, enhance employee experience, and increase organizational effectiveness. Collaborate cross-functionally with HR Operations, Talent Acquisition, Total Rewards, and other HR partners to deliver integrated people solutions. Change Management & Culture Develop change strategies that support leader alignment, employee engagement, and successful adoption Coach leaders through moments of change and complexity with empathy, clarity, and sound judgment Serve as a culture ambassador, helping reinforce Relay’s values and build an inclusive, high-performing environment Qualifications Bachelor’s degree required; advanced degree or HR certification preferred. 10+ years of progressive Human Resources experience , including significant HR Business Partner experience. Demonstrated experience serving as a strategic advisor to senior leaders an