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Company Overview: Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn  and Facebook . Role Summary: The Director of Imaging Biomarkers lead s  the development and execution of innovative imaging strategies across Dyne’s therapeutic programs.  This  pivotal  role  will  ensur e  that imaging biomarker strategies are scientifically rigorous, clinically relevant, and condu cive to robust therapeutic development. The person in this  role focuses on enhancing the understanding of disease  mechanisms ,  patient populations,  evaluating therapeutic efficacy, and supporting clinical  trial  designs through innovative imaging approaches.  This role is cri tical to linking early phase research to clinical development,  providing  essential insights that drive decision making.  The person in this role  leverages  their  expertise  in various imaging modalities to develop novel biomarker applications that assess therapeutic efficacy, drive patient-centric trial designs, and  facilitate  regulatory approval processes.  This role combines scientific depth with strategic vision, driving the discovery, validation, and application of advanced imaging modalities to enable precision medicine and accelerate drug development. The  person in this role  serve s  as a trusted expert and collaborative leader, fostering innovation and ensuring scientific rigor in both preclinical and clinical settings .     This role is based in Waltham, MA.    Primary Responsibilities  Include :   Collaborate with cross- functional  teams including clinical development, biostatistics, and regulatory affairs to  ensure  that imaging biomarkers are effectively integrated into clinical trial protocols   Enable the delivery of high-quality data supporting both internal decision making and external communications with stakeholders, including regulatory authorities    Define and execute the imaging biomarker strategy aligned with clinical and translational objectives   Serve as the subject matter expert for imaging biomarkers across  pre-clinical  and clinical programs   Lead the  development , validation, and qualification of imaging biomarkers for disease characterization, patient stratification, and pharmacodynamic assessment   Partner with Clinical Development, Translational Biomarkers, Biostatistics, Data Management and Regulatory teams to integrate imaging biomarkers into Dyne clinical trials   Evaluate and implement   cutting-edge  imaging technologies (e.g., MRI, PET, CT, ultrasound, optical imaging)   Ensure compliance with regulatory standards for imaging biomarker development and qualification   Collaborate with external imaging CROs, academic institutions, and technology vendors to deploy imaging biomarkers into Dyne clinical trials   Oversee vendor selection and budget management for imaging-related activities   Manage imaging biomarker operations in clinical studies including protocol development, support site training, and data quality assurance