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Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.   Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking a Sr. Scientist, Lentivirus Upstream Processing as part of the Technical Development team based in Somerset, NJ.   Role Overview The Senior Scientist, Lentivirus Upstream Process Development, will be a core technical contributor responsible for designing, executing, and optimizing upstream production processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality, high-titer vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will apply technical expertise in upstream processing (USP)—including seed train optimization, mammalian cell culture (HEK293/HEK293T), large-scale transient transfection, and bioreactor scale-up—to ensure processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strong analytical thinking to support project timelines while maintaining a patient-focused approach.   Key Responsibilities Design and execute experimental strategies for lentiviral vector upstream production. Perform development and optimization of upstream processes, including seed train expansion, suspension mammalian cell culture (HEK293/HEK293T), plasmid transient transfection optimization, and feed batch/perfusion bioprocessing in stir-tank and rocker bioreactors. Support the establishment and validation of bioreactor scale-up and scale-down models to ensure process comparability and predictability. Support the translation of bench-scale processes to GMP manufacturing, assisting in technology transfer and providing troubleshooting support during clinical production runs. Execute study protocols to define operating parameters, feeding strategies, and performance limits; maintain accurate documentation for USP data. Communicate technical findings, issues, and potential delays to project leads in a timely manner. Collaborate with cross-functional team members, including CMC Project Management and other technical leads, to support project goals. Apply scientific knowledge and technology to optimize vector titer, specific productivity, and quality. Support team activities by providing technical guidance to junior staff, fostering a culture of scientific rigor and continuous improvement. Author and review technical documents, including development reports, SOPs, and relevant sections for regulatory submissions (IND). Work closely with Downstream Process Development and Analytical Development teams to ensure integrated process outcomes. Support tech transfer activities to/from other Legend sites or CDMOs. Ensure compliance with all internal and regulatory requirements.   Requirements Advanced degree (PhD preferred, or MS) in Chemical Engineering, Bioengineering, or a related field. Experience: 5-8 years (PhD) or 8+ years (MS) of experience