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Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California. Summary: We are seeking an experienced Software Engineer Lead to provide technical leadership for the development, enhancement, and support of software applications in a regulated clinical laboratory environment. This role will lead the design and delivery of software solutions, guide engineering best practices, mentor team members, and collaborate closely with business and technical stakeholders to deliver secure, reliable, and compliant applications. The ideal candidate combines strong software engineering expertise, hands-on development experience, operational awareness, and experience working in regulated healthcare environments. This individual will serve as a technical leader for the team, driving software quality, architectural consistency, and successful project execution while supporting critical laboratory and business operations. Onsite: Monday, Tuesday, and Thursday  Responsibilities: Lead the design, development, testing, deployment, and maintenance of software applications supporting laboratory and business operations. Be a hands-on implementation lead for software projects using the latest technologies for software development and integrations, and also manage a small team of engineers for this. Participate actively in software design, code reviews, troubleshooting, and implementation activities. Be a champion of software best practices in partnership with QA by conducting risk analysis, identifying test data, and improving CI/CD within Informatics and stakeholder  teams aimed at high quality deliverables. Promote engineering best practices for software quality, security, performance, maintainability, and reliability. Support Agile development processes including sprint planning, backlog refinement, estimation, and release planning. Ensure software solutions comply with applicable regulatory requirements including HIPAA, CLIA, CAP, FDA (as applicable), and internal quality standards. Support validation, documentation, audit readiness, and compliance activities. Requirements: Bachelor's degree in Computer Science, Information Technology, Engineering, or related field. 6+ years of software development experience. 2+ years serving as a technical lead, senior engineer, or equivalent leadership role. Demonstrated expertise across the full software development stack, including Python, Java, JavaScript, database design and management, DevOps practices, CI/CD automation, and modern software engineering principles. Experience working in a regulated healthcare, diagnostics, laboratory, or life sciences environment. Experience supporting production applications and resolving complex technical issues. Experience working with distributed or offshore development teams. Experience with enterprise application and automation system integrations. Strong understanding of Agile methodologies including Scrum and Kanban. Experience with cloud platforms such as AWS