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Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity: The Medical Review Physician plays a critical role in ensuring the safety of pharmaceutical products across their lifecycle by providing medical oversight of safety data, including clinical trials and post-marketing surveillance. This role sits at the intersection of clinical safety and data analysis, translating safety information into actionable insights that protect patients and inform benefit–risk decisions. Responsibilities: Medical Review & Case Assessment Serves as a safety medical expert to evaluate Individual Case Safety Reports (ICSRs) and perform medical review of Serious Adverse Events (SAEs) from various sources, including clinical trials, literature, and post-marketing sources. Assess causality, seriousness, and expectedness of adverse events using clinical judgment and regulatory frameworks. Ensure accurate medical evaluation, coding (e.g., MedDRA), and completeness of safety data. Review case narrative and medical contents for completeness, identify missing medical information or key data that impact medical understanding and evaluation of the case, and issue safety medical queries. Review and approve the Analysis of Similar Events and provide company comments and assessment with medical analysis for SUSAR/IND Safety Reports. Provide overall case assessment and pharmacovigilance comment on ICSRs as needed. Leadership Provide medical leadership for case review activities across Global Patient Safety, including prioritization and oversight of medically significant or complex safety cases. Serve as a key escalation point for case-level medical issues, advising Product Safety Lead Physicians, Safety Scientists, Medical Monitors, and Safety Operations partners as needed. Help shape a consistent, high-quality approach to medical review by mentoring new team members and sharing best practices in clinical assessment, causality, expectedness, and case interpretation. Lead or support training for internal teams and vendors involved in medical review activities to strengthen quality, consistency, and inspection readiness. Contribute medical expertise to cross-functional initiatives, process improvements, and governance discussions related to patient safety and pharmacovigilance operations. Act as a subject matter expert for medical review during audits, inspections, and other quality or compliance-related activities. Drive accountability and excellence in medical review by identifying trends, recommending improvements, and partnering across functions to resolve issues efficiently. Cross-functional Collaboration Partner with Clinical Development, Regulatory Affairs, Biostatistics, Safety Science, Safety Surveillance, and Safety Operations. Collaborate with Safety Science for signal detection activities and risk management planning, as required. Serve as a medical safety expert on cross-functional teams and governance forums. Communicate safety findings and recommendations to internal and external stakeholders. Compliance & Quality Ensure compliance with global pharmacovigilance regulations and guidanc