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About RTW Investments RTW Investments, LP (“RTW”) is a global, full life-cycle investment and innovation firm dedicated to solving the most challenging, unmet patient needs. We are focused on company building and identifying transformational and disruptive innovations across the biopharmaceutical and medical technologies sectors. Our investment philosophy combines a deep understanding of disease, biology, medicine, and technology with a comprehensive view of commercial opportunities and challenges. Our talented team brings hands-on expertise in targeted areas of innovation, dedicated to the diligent exploration and support of emerging breakthroughs in both industry and academia. Our mission is simple: we power breakthrough therapies that transform the lives of millions. RTW Investments – Recent Press   Overview RTW Investments is seeking a highly effective Director of Human Resources to serve as the senior executor and integrator for HR across a hedge fund and its portfolio of newly formed companies. This role is the right hand to the Head of HR and is accountable for building, running, and continuously improving the HR operating system - spanning people operations and recruiting - across multiple entities. In keeping with the firm’s ethos, this is a hands-on role. The Director of HR owns core HR operations, runs the recruiting engine, and personally leads recruiting for priority roles where speed, judgment, or complexity matter. The ideal candidate is a low-ego, systems-driven operator who thrives in complex environments, brings structure to ambiguity, and ensures consistent, high-quality execution. This role is a unique opportunity to become an important part of the Firm Services at RTW.   Key Responsibilities HR Operations & Infrastructure Own and optimize core people operations across the hedge fund and its portfolio companies Build, standardize, and continuously improve HR processes, including onboarding, performance cycles, compliance, and onboarding and offboarding Own HR systems and data integrity; ensure accuracy, scalability, and operational rigor Translate evolving firm needs into durable HR infrastructure that can support multiple entities at different stages   Partnership & Integration on the HR Team Partner closely with the Head of HR to translate people strategy and organizational design into executable plans Act as the integrator across HR initiatives, ensuring priorities are clear, work is coordinated, and execution stays on track Establish operating cadence, dashboards, timelines, and check-ins to provide visibility into headcount, hiring, and HR operations Surface risks, gaps, and execution issues early; drive resolution Coach and develop HR team members; provide structure, clarity, and accountability Raise the bar on execution quality, follow-through, and operating rigor   Recruiting & Talent Execution Design, formalize, and operate a consistent recruiting framework across the fund and newcos Personally recruit for priority, complex, or high-impact roles, in close partnership with the Head of HR and business leaders Support leaders with practical guidance on role scoping, interview process, and decision-making Ensure recruiting execution is fast, disciplined, and aligned with firm standards to support high-quality hiring   Qualifications and Skills 8–12 years of progressive HR experience, ideally in hedge funds, private investment firms, or high-growth, multi-entity environments Exceptionally strong operator with a track record of building and running scalable HR systems Comfortable balancing hands-on execution with senior-level partnership Highly systems-oriented, detail-driven, and organized Low ego, high ownership; thrives as a trusted second-in-command Strong judgment and discretion in high-performance, confidential environments Effect